国产人妖在线视频I午夜av一区二区三区I国产色一区二区I一级片视频在线观看I一级毛片儿I亚色图I丁香花一区二区I超碰97在线免费I久久精品中文字幕I日韩在线视频观看免费I无码中文字幕色专区I欧美专区亚洲专区I国产tv在线观看I2024最新黄色网址I日本老妇高潮乱hdI成人免费入口I日韩精品视频在线看I国产传媒在线播放I一本岛视频在线观看I自拍日韩亚洲一区在线I国产成人亚洲综合a∨婷婷I国产精品2019I色亚洲天堂Iav黄色免费I欧美大尺度视频

Chemokinetic Therapy (CDT) uses Fenton reaction catalyst to kill tumor cells by converting hydrogen peroxide (H2O2) in cells into hydroxyl radicals (OH•). Although there are many studies on supplementing H2O2 to improve the therapeutic effect of CDT, there are few studies focusing on the application of superoxide radicals (O2−•) in CDT, which may lead to better therapeutic effects. One of the main problems with O2-•mediated CDT is that it may induce severe oxidative damage to normal tissues, which can be solved by using degradable O2-• scavengers. Here, Jiang Hulin of China Pharmaceutical University constructed a harmless-harmful switchable continuous laccase (LAC)-mediated killing strategy (HULK), which is the first LAC-mediated acceleration of O2−• production The CDT reagent, due to the photodegradation of the O2−• scavenger FeCe6, has a harmless-harmful switchable effect.
LAC-mediated substrate oxidation can effectively catalyze the production of O2−• in cells, thereby promoting the conversion of Fe3+ to Fe2+, accelerating the production of OH•, and inducing tumor cell apoptosis and necrosis. The O2−• scavenger FeCe6 is rapidly photodegraded during the radiation process, and LAC-mediated O2 −• generation realizes activatable CDT therapy. This study not only proposed for the first time the LAC-mediated O2−• generation strategy, but also provided new insights for the treatment of activatable CDT.

Tian-Jiao Zhou, et al. A Harmless–Harmful Switchable and Uninterrupted Laccase-Instructed Killer for Activatable Chemodynamic Therapy, Adv. Mater., 2021.

DOI: 10.1002/adma.202100114