Mitochondrial energy metabolism PCR array
| 【Numbering】BKMI100010 | 【CAS】CAS | ||
| 【Item No.】BKMI100010-1 | 【specification】 | ||
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【 Main advantage 】
Mitochondria act as a cell's energy source and are essential for the normal growth and function of eukaryotic cells. NADH and FADH2 (metabolites of the glycolysis and TCA cycles) are oxidized into the inner mitochondrial membrane by a series of four protein complexes: NADH CoQ reductase, succinic CoQ reductase, CoQ-cytochrome c reductase, and cytochrome c oxidase. The free energy produced by these processes drives oxidative phosphorylation and ATP synthesis via a fifth protein complex (ATP synthase). Dysregulation of these processes is a major pathological consequence of cancer progression. Many tumors contain a reduced number of mitochondrial respiratory chain components, although the exact mechanism of this inhibition is unknown. However, recent studies have shown that the important tumor suppressor p53 induces the expression of COX2, which is an important component of cytochrome c oxidase function. Mitochondrial dysfunction can also lead to metabolic syndrome and obesity, where excess - oxidation overloads oxidative phosphorylation by producing excess NADH.
The WCGENE® PCR Array Plate is simple to operate. It is only necessary to mix the cDNA and qPCR mix, then add it to each hole, and then test it on the machine, so that the differentially expressed genes in the sample can be found by analyzing the qPCR results. It has the characteristics of high repeatability, strong sensitivity and convenient operation. It saves the complicated process of pre-experiment, primer validation, literature selection gene and so on for experimental researchers, and can directly understand the differences of key genes in different signaling pathways or diseases.
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