Ferroptosis PCR Array
| 【Numbering】BKMI100000 | 【CAS】CAS | ||
| 【Item No.】BKMI100000-1 | 【specification】 | ||
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Name: Ferroptosis PCR Array
Species: Human
Item Number: wc-mRNA0271-H
Specification: 96 hole plate
Brand: WCGENE ® biotech
Products: 96-well prefabricated primer board, sealing plate film, manual
Storage: -20℃
Validity: six months
This product is for scientific use only and should not be used to diagnose, prevent or treat diseases.
Iron death is a regulated form of cell death that has been the subject of recent research. When iron death occurs in cells, there is smaller concentration of mitochondrial membrane density than normal mitochondria, reduction or disappearance of mitochondrial ridge, and rupture of mitochondrial outer membrane.
Participation in iron death processes includes activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine-glutamate reverse transporters. The process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) from iron metabolism and can be passed through iron chelating agents and lipid peroxidation inhibitors. GPX4, HSPB1, and NRF2 act as negative regulators of iron death by restricting ROS production and reducing cellular iron uptake, respectively. In contrast, NOX and P53 act as positive regulators of iron death by promoting ROS production and inhibiting SLC7A11 expression, respectively. Dysregulation of iron death is associated with a variety of physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, ischemia/reperfusion injury of the liver and heart, and T cell immunity.
The Vogi gene cell iron death PCR array includes 90 key genes such as iron ion, mitochondrial function regulation, GSH homeostasis regulation and REDOX.
The WCGENE® PCR Array Plate is simple to operate. It is only necessary to mix the cDNA and qPCR mix, then add it to each hole, and then test it on the machine, so that the differentially expressed genes in the sample can be found by analyzing the qPCR results. It has the characteristics of high repeatability, strong sensitivity and convenient operation. It saves the complicated process of pre-experiment, primer validation, literature selection gene and so on for experimental researchers, and can directly understand the differences of key genes in different signaling pathways or diseases.
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance.The website pictures are from the Internet. The pictures are for reference only. Please take the real object as the standard. In case of infringement, please contact us to delete them immediately. |
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