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Carboxyl magnetic beads are superparamagnetic magnetic particles with carboxyl functional groups on the surface. They are a kind of functional biological magnetic beads. They can gather rapidly in the magnetic field and help to disperse evenly after leaving the magnetic field. It is mainly used for the preparation of immunomagnetic beads. Si COOH magnetic microspheres are monodisperse and non agglomerated in regular spherical shape. They have the characteristics of superparamagnetism, rapid magnetic response, rich carboxyl functional groups, monodispersity and submicron particle size. They can covalently couple biological ligands such as peptides, proteins, antibodies and oligonucleotides to the surface of microspheres under the action of special chemical reagents (such as EDC), It is an important carrier tool in medical and molecular biology research.






Compared with traditional polydisperse magnetic beads, Si COOH is monodisperse carboxyl magnetic beads with uniform particle size and excellent dispersion performance; Compared with traditional multi-core magnetic beads, Si COOH is a single core magnetic bead, and the thickness of silicon layer is about 1 / 20 of the size of magnetic beads. Therefore, the magnetic content of magnetic beads is more than 95%. It has faster magnetic response, while maintaining good dispersion of microspheres, very low nonspecific adsorption and richer binding sites. Based on the excellent characteristics of Si COOH, it is very easy to realize rapid separation under the magnetic field and rapid re suspension and dispersion after withdrawing from the magnetic field, especially suitable for automatic coupling operation. Due to the uniform size of Si COOH monodisperse carboxyl magnetic beads, the inter batch difference of the experiment can be significantly reduced.










■ product performance






Rich carboxyl content: > 100 μ Mol / g, which can be used for rapid coupling and binding of target substances;






Good operation performance: the magnetic beads are evenly dispersed, superparamagnetic, the saturation magnetization is 70-80 EMU / g, and the magnetic corresponding time is less than 10s;






Isoelectric point: Si COOH isoelectric point is about pH2 5；






Good stability and repeatability between batches: uniform particle size and monodisperse;






High binding amount of target substance and low nonspecific adsorption: it is specially used in the field of separation and purification.






Good storage stability: complete silicon oxide coating, stable service performance, resistance to 6m hydrochloric acid corrosion > 5 minutes.










■ application direction






1. Biological macromolecules are coupled on the surface of magnetic beads for separation, purification or analysis and detection (such as cells, proteins, sugars, nucleic acids, etc.);






2. Used for specific nucleic acid separation and purification;






3. For immunoassay and cell sorting;






4. For biosensors;






5. Used for drug screening and delivery.










■ precautions






1. Magnetic beads stored in deionized water, freezing, drying and centrifugation may affect the use effect of magnetic beads;






2. It is normal for magnetic beads to settle due to gravity. Before using this product, please fully oscillate or ultrasonic to keep the magnetic beads in a uniform suspension state;






3. This product needs to be used with magnetic separation equipment;






4. 20% ethanol can be stored stably at 2-8 ° and the shelf life is 2 years;

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