Amide bond to ring
| 【Numbering】BK2021071403 | 【CAS】CAS | ||
| 【Item No.】 | 【specification】 | ||
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Studies have shown that polypeptides with an α-helical structure and rich in positive charges can pass through cell membranes. Therefore, people have developed the use of disulfide bonds, lactam bonds and book binding
Peptides serve as the α-helical structure of the scaffold. For peptides with amide bonds forming a ring, a very popular research is the RGD series of cyclic peptides, a protection strategy for the maturity of synbiotics.
And through the method of solid phase-liquid phase combination, it is possible to realize the ring formation of the amide bond of the peptide head and tail, the ring formation of the amide bond of the peptide side chain and the complete RGD series of cyclic peptides.
Amide bond-peptide ring formation
By differentially protecting and removing the a-amino group of the N-terminal amino acid of the polypeptide, and then condensing this a-amino group with the C-terminal carboxyl group of the polypeptide, high quality head and tail can be achieved
Cyclic peptide. The purity can reach 98% HPLC
Amide bond-polypeptide side chain forming ring
By selectively protecting and removing the side chain amino group of Lys or Orn and the carboxy group of Glu or Asp side chain, the exact site of the polypeptide can be looped. Can be synthesized
Message
Peptides serve as the α-helical structure of the scaffold. For peptides with amide bonds forming a ring, a very popular research is the RGD series of cyclic peptides, a protection strategy for the maturity of synbiotics.
And through the method of solid phase-liquid phase combination, it is possible to realize the ring formation of the amide bond of the peptide head and tail, the ring formation of the amide bond of the peptide side chain and the complete RGD series of cyclic peptides.
Amide bond-peptide ring formation
By differentially protecting and removing the a-amino group of the N-terminal amino acid of the polypeptide, and then condensing this a-amino group with the C-terminal carboxyl group of the polypeptide, high quality head and tail can be achieved
Cyclic peptide. The purity can reach 98% HPLC
Amide bond-polypeptide side chain forming ring
By selectively protecting and removing the side chain amino group of Lys or Orn and the carboxy group of Glu or Asp side chain, the exact site of the polypeptide can be looped. Can be synthesized
Stable high-quality products.
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